Adult ENT-Pro™ and Children’s ENT-Pro®
are pleasant-tasting strawberryflavored probiotic lozenges that supply newly isolated Lactobacillus delbrueckii LE and Lactobacillus rhamnosus LB3 strains, along with Lactobacillus plantarum
LM, Bifidobacterium longum and Bifidobacterium bifidum, combined to support otolaryngeal health and overall immune health. Probiotics are classically defined as a “preparation of, or a product containing viable, defined microorganisms in sufficient numbers, which alter the microbiota in a compartment of the host, and exert beneficial health effects in the host”.
Traditionally, probiotics are used to influence the microbial balance specifically in the gastrointestinal tract, which is host to billions of diverse and metabolically active organisms. These microorganisms have been found to influence metabolic function, inform the immune system, protect against pathogens, affect brain function and even steer genetic expression through epigenetic mechanisms. Probiotics have played a key role in the competitive inhibition mechanism where the “good bacteria” outweigh the “bad bacteria,” and theoretically shift the microbial balance towards benefitting the host’s overall health.
However, with acute infections, such as those afflicting the ear, nose and throat areas, antibiotics are often prescribed in order to address the pathogens. In some cases of persistent infection, surgery may even become necessary to avoid further complications such as hearing loss. Otitis media (OM) is one of the most common diagnoses made by pediatricians. Other diagnoses affected by viral and bacterial pathogens within the otolaryngeal cavity include tonsillitis (inflammation of the pharyngeal tonsils), sinusitis, pharyngitis (sore throat),and inflammation of the adenoids.
In search of natural and potent ways to support otolaryngeal health, with no negative side effects, renown microbiologist Liubov Sichel, PhD, created the target-specific probiotic formulations, Adult ENT-Pro™ and Children’s ENT-Pro®.
Target-specific probiotic formulations are designed to promote the biological mechanisms that support the health of specific tissues and organs.
Adult ENT-Pro™ and Children’s ENT-Pro® provide specific probiotics targeted to support sinus structures and surrounding tissues. These strains also promote overall immune-modulating qualities.(1)
Unlike other probiotic strains targeting otolaryngeal health, such as Streptococcus salivarius, the strains found in Adult ENT-Pro™ and Children’s ENT-Pro® are not considered opportunistic pathogens, which can be detrimental under certain circumstances.(2) Rather, they are safe and well-researched strains, exhibiting high levels of pathogen-specific activity and immune-modulating behavior. Safety assessments confirm the strains are non-toxic and have no embryotoxic, mutagenic, teratogenic or carcinogenic effects.
ENT Health Clinical Data
Clinical testing was performed in the Hospital of Institute of Otolaryngology Academy of Medical Sciences, Kiev, 2002-2006, for State Program “New Probiotics for Otolaryngology”. Strains of L. delbrueckii LE and L. rhamnosus LB3, as well as combination blends, were found to demonstrate high levels of antagonistic activity towards the microbes most frequently found in chronic and recurring ENT infections. In addition to showing a high degree of adhesion to the mucous coat of the upper air passages, application of the formulation resulted in a statistically reliable increase of the number of tonsillar cells producing IgA, as well as increased activity of the natural cytotoxic tonsillar cells, and increased number of tonsillar cells with surface antigens CD25 and CD56.
Probiotic formulations based on these strains also induced a proficient immune response by TH1-type cytokines,inhibited fatty cellular infiltration of tonsils tissue, and stimulated progression of B-cell lymphocytes and high glycogen macrophages. It was observed that this probiotic formulation stimulated IFN up to 4.5-fold, induced production of the IL-4, increased IgG and IgA up to 2.5-fold, and intensified glycogen synthesis in phagocytes. L.rhamnosus LB3 demonstrated more effective activation of humoral immune response; whereas, L. delbruekit LE showed mostly cell-mediated immune response.
In one study, tonsillar cells from patients with adenoid disease were cultivated with L. rhamnosus LB3. After four hours, L. rhamnosus LB3 had increased the number of cells with membrane antigen CD25 (activated cells),increased the number of IgA producers by 30%, and intensified the functional activity of the natural cytotoxic cells 3.4 times as much.
The specific combination of lactobacilli and bifidobacteria strains found in Adult ENT-Pro™ and
Children’s ENT-Pro® also demonstrate antagonistic action in relation to a number of ENT pathogens, and help support a healthy immune response.
Adult ENT-Pro™ and Children’s ENT-Pro® consist of probiotic strains that are resistant to gastric secretions,bile salts, gastrointestinal enzymes and acids, giving them very high survivability ratings. They are described as perfect strains to support optimal otolaryngeal immune health.(3)
Lysozymes
In addition to the probiotic strains, these probiotic formulas include lysozymes. A lysozyme is an enzyme often used to lyse bacterial cells by hydrolyzing the peptidoglycan in the cell walls.
Lysozymes, first discovered by Alexander Fleming in a search for something to slow bacterial growth, exhibit selective antibacterial properties for oral microorganisms, and are naturally found in the saliva and tears as part of the innate immune system⁴. Lysozymes are considered especially advantageous in the support of a healthy respiratory tract (US Patent 9,950,041), and have recently received Novel Food Status in the European Union (EU) 2018/991.
Adult ENT-Pro™ and Children’s ENT-Pro®
• Promote the biological mechanisms that support otolaryngeal tissues and organs
• Adhere to oral cavity mucous coat
• Demonstrate high survivability under both acidic and alkaline environments
• Show antagonist activity towards opportunistic microflora, including Candida strains
• Exhibit immuno-modulating effects
• Activate immunocompetent cells by CD25+, CD56+ antigens, NK cells, IFNs
• Stimulate production of B cell lymphocytes, IgA
• Demonstrate high clinical result with positive effect on the microbiocenosis of the upper air passages
• Possess activating effect on a wide range of responders on tonsillar cells
Recommended Use:
• As a daily probiotic, take 1 lozenge per day.
• When needing extra immune support, take up to 4 lozenges per day.
• For best absorption, place under the tongue to dissolve. Hold in the oral cavity for about 60 seconds.
